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01 / What is it?
What is it?
PT-141, also called bremelanotide, is a laboratory-made cyclic peptide. It activates melanocortin receptors, which act like signalling switches in the body and brain.
The signalling chain
Follow the connection.
A simplified view of the proposed or studied pathway for PT-141 (Bremelanotide).
Bremelanotide
Why do people find it interesting?
Bremelanotide affects brain pathways involved in sexual desire and arousal. Unlike medicines that mainly increase blood flow, it works through the melanocortin signalling system.
What might you notice?
You may notice a stronger interest in sexual activity and find it easier to become aroused. Some people report noticing these effects within about 30 to 60 minutes after use.
What happens in your body?
Melanocortin receptors are involved in several body functions, including sexual function, appetite, energy balance and pigmentation. This is why a drug acting on this system can have effects beyond sexual desire.
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Important to know
The most commonly reported side effect is nausea, especially after the first few doses. Some people may also experience flushing, headaches or tiredness. A temporary increase in blood pressure can also occur after use.
Read the scope & limitations ↗︎Practical context
Dose information from the guide
The recommended dose is 1.75 mg. No more than 1 dose should be used within 24 hours. We recommend no more than 8 doses per month.
This profile is general information, not medical advice or a recommendation to use a substance. Research findings and individual responses differ. Read the full scope.